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awesome-python这个awesome系列基本囊括了python的杀手应用了吧
杀手级这个词太暴力，只能根据你不同的需求提不同的杀手了。 fuckit.py https://github.com/ajalt/fuckitpy scapy
排名不分先后：
Django/Flask 快速建站
Scrapy 支持分布式抓取 配合redis有奇效
Numpy/Scipy 各种酷炫的计算
urllib/urllib2 干坏事必备库之一
Selenium 干坏事必备库之二
requests 利用了urllib3的新特性连接池
别私信问我怎么干坏事，哼。
Openstack https://github.com/vinta/awesome-pythonA curated list of awesome Python frameworks, libraries and software 用了这么多年python，我想说已经死去的zope2还是很nb的，真的。其他的功能都有替代品，但是当年的zope2还基本没有替代。不想耽误大家，大家千万不要再去折腾zope，因为他后来放弃了自己的杀手特性，自杀了
好，谢谢 @absente 的评论，刚刚看了下，现在基于Pyramid+ZODB的框架 Substance D Web Application Server 是一个替代。基本上是完全山寨zope2，是对zope2的一个致敬（刚刚看了发起人，就是当年zope那帮老鸟啊！）。当然这个SubstanceD估计难发展到当年zope的高度，因为到现在再建立当年zope辉煌时候的生态太难了。 想来想去就只有OpenStack了，这块目前py应该还是领先世界的，这才称得上超级牛逼。
不过Go所代表的docker甚至Kubernetes也是在迅速赶超的。个人对py的未来表示悲观。 matplotlib + iPython Notebook
功能够用而且免费开源，穷学生的福音 框架都很水，此处略；
论第三方库的话，zope.interface，没有之一；
应用的领域太广，基本没有可比性，可略。
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