GTEx is a comprehensive database containing gene expression data from human tissue samples. Its content includes RNA sequences, eQTL data and other relevant information from 53 tissue types. Uses include understanding tissue-specific gene expression, identifying disease-related genes, studying gene regulation and developing personalized medicine.
What is GTEx database?
GTEx (Gene Expression Histology) database is a comprehensive resource containing gene expression data and related information for human tissue samples.
Database content:
The GTEx database collects samples from more than 700 donors, covering 53 tissue types, including all major organs and tissues. The samples were organized into over 15,000 RNA sequence (RNA-Seq) and microarray data sets.
Data type:
- Gene expression: Records the expression level of genes in each tissue.
- eQTL data: Identifies specific genetic variants that affect gene expression.
- Other relevant data: Includes histological information, clinical phenotype and transcriptomic information.
Purpose:
The GTEx database provides a valuable resource for biomedical research. It can be used to:
- Understand tissue-specific gene expression:Determine the expression patterns of different genes in different tissue types.
- Identify disease-related genes: Identify disease-related genes by comparing gene expression in disease patients and healthy individuals.
- Study gene regulation: Use eQTL data to study the genetic factors that affect gene expression.
- Develop personalized medicine: Develop treatments that target specific tissues by analyzing tissue-specific gene expression.
Data access:
Data from the GTEx database can be obtained for free from its official website. Users can filter datasets by tissue type, genes, or other metadata.
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