近日,美国治疗公司 Pear Therapeutics 宣布完成 2000 万美元 A 轮融资,将用于其数字组合疗法 “eFormulations” 的研发与落地。Pear Therapeutics 旨在通过数字健康与药物疗法的组合使用,来帮助患有药物滥用症、精神分裂症的患者。
根据该公司的声明,本轮投资由 5AM Ventures, Arboretum Ventures,以及 JAZZ VenturePartners 领投,Bridge Builders Collaborative 和其他一些投资机构跟投。
该公司计划在 2016 上半年向 FDA(the U.S. Food and Drug Administration,美国食品药品管理局)提交其数字疗法 reSET 来治疗药物滥用症(Substance Abuse Disorder)。reSET 和 reSET-O 分别为面向患者的智能手机 APP 和面向临床医生的 WEB 接口。reSET 和 reSET-O 已经在六项随机的临床研究中进行了测试,参与测试的患者有 1500 名。
(Pear Therapeutics 通过数字化应用,来提高药物的疗效)
在关键的随机试验中,399 名患有与毒品滥用症(SUD,substanceuse disorder)相关病症、寻求治疗的患者在 10 家治疗中心接受了面对面诊疗和 reSET 在线诊疗。这些毒品包括可卡因、酒精、大麻、以及兴奋剂等。试验表明,接受 reSET 在线诊疗的患者比起面对面诊疗的患者在治疗中表现出更高的禁欲率和保留率。
reSET-O 结合了 reSET 模块和药物疗法,来对抗对*制剂(通常用于镇痛或催眠)的依赖症。在三项随机的临床试验中,有超过 465 名患者参与。该公司称其 reSET-O 产品在试验中能够增强患者的禁欲率和保留率,并减少对*制剂依赖症患者的临床干预时间。
这是目前进行多个大规模临床试验所申请的双重治疗方法,可以治疗精神分裂症、情感分裂性精神障碍以及双相情感障碍。
Pear Therapeutics 公司结合数字健康和药物的疗法实际上是一种被广泛应用的趋势。比如 Proteus Digital Health 与 Otsuka Pharmaceuticals(大冢制药公司)提交了新药申请,使用无线传感器和可穿戴设备,与 Otsuka Pharmaceuticals 的治疗药 Abilify(阿立哌唑) 来改善精神分裂症患者的服药依从性。它也能显示药物对人的影响。因此,医生可以确定是否需要进行剂量修改,来达到更好的治疗效果。Proteus 的方法最初被 Barton Health system(巴顿卫生系统)应用到高血压病患者身上。此外,其他公司针对服药依从性也开发了不同的方法,比如 AL Cure 、 Medisafe 和 AdhereTech。
本文编译自: medcitynews.com ,如若转载,请注明出处:http://36kr.com/p/5043126.html
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